Rules for classification and labelling of chemicals — Part 26: Specific target organ toxicity — Repeated exposure
1 Scope
This part of GB 30000 specifies the terms and definitions, general descriptions, classification, judgment logic and labels of chemicals with specific target organ toxicity caused by repeated exposure.
This part is applicable to the classification and labelling of chemicals with specific target organ toxicity caused by repeated exposure according to the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
2 Normative references
The following referenced documents are indispensable for the application of this document. For dated references, only the edition cited applies. For undated references, the latest edition of the referenced document (including any amendments) applies.
GB 13690 General rule for classification and hazard communication of chemicals
GB/T 16483 Safety data sheet for chemical products - Content and order of sections
GB 30000.25 Rules for classification and labelling of chemicals — Part 25: Specific target organ toxicity — Single exposure
The United Nations Recommendations on the Transport of Dangerous Goods: Model Regulations (Rev.17)
The United Nations Globally Harmonized System of Classification and Labelling of Chemicals (Rev.4)
3 Term and definition
For the purposes of this document, the term and definition given in GB 13690 and the following apply.
3.1
specific target organ toxicity-repeat exposure
specific and non-lethal target organ toxicity caused by repeated exposure to substances and mixtures, including all obvious health effects, functional damage (reversible and irreversible, immediate and delayed)
4 General description
4.1 The classification may determine that the substance or mixture has specific target organ toxicity, and that such substance or mixture may have potentially harmful effects on the health of contacts.
4.2 Classification depends on whether there are reliable proofs. These proofs indicate that repeated exposure to substances or mixtures produces consistent and identifiable toxic effects on humanity, or produce toxicologically significant changes on the function or morphology of tissues/organs in experimental animals, or seriously changes biochemistry or blood of organisms. These changes are related to human health. Human body data will be the main source of proofs for this hazard category.
4.3 The assessment shall combine not only significant changes in a single organ or biological system, but also general changes involving multiple lower-seriousness organs.
4.4 Specific target organ poison may occur through any way related to humanity, that is, mainly through mouth, skin or inhalation.
4.5 See GB 30000.25 for the classification of specific target organ toxicity of single exposure. Other specific toxic effects, such as acute toxicity, severe eye injury/eye irritation and skin corrosion/irritation, respiratory or skin sensitization, carcinogenicity, germ cell mutagenicity, reproductive toxicity and inhalation toxicity, are evaluated separately, therefore, they are not included in this part.
5 Classification standard
5.1 General principles
See GB 13690 for general principles of classification and labelling of specific target organ toxicity-repeated exposure.
Foreword i
1 Scope
2 Normative references
3 Term and definition
4 General description
5 Classification standard
6 Judgment logic
7 Labelling
Annex A (Informative) Judgment logic of repeated exposure to specific target organ toxicity
Annex B (Normative) The allocation of label elements for repeated exposure to specific target organ toxicity
Annex C (Normative) Classification standard and label elements of repeated exposure to specific target organ toxicity
Annex D (Informative) Hazard statement and precautionary statement of repeated exposure to specific target organ toxicity
Annex E (Informative) Label examples of repeated exposure to specific target organ toxicity
