——Part 25: Specific target organ toxicity - Single exposure (replaces GB 20599-2006);
——Part 26: Specific target organ toxicity - Repeated exposure (replaces GB 20601-2006);
——Part 27: Aspiration hazard;
——Part 28: Hazardous to the aquatic environment (replaces GB 20602-2006);
——Part 29: Hazardous to the ozone layer;
——Part 30: Warning Signs in Chemical Workplaces;
This is Part 22 of GB 30000.
1 Scope
This part of GB 30000 stipulates the terms and definitions, classification standards, judgment logic and guidance and labels of chemicals with germ cell mutagenicity.
This part is applicable to the classification and labelling of chemicals with germ cell mutagenicity according to the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
2 Normative references
The following referenced documents are indispensable for the application of this document. For dated references, only the edition cited applies. For undated references, the latest edition of the referenced document (including any amendments) applies.
GB 30000.23 Rules for classification and labelling of chemicals - Part 23: Carcinogenicity
GB 13690 General rule for classification and hazard communication of chemicals
The United Nations Globally Harmonized System of Classification and Labelling of Chemicals (GHS) (Rev.4)
The United Nations Recommendations on the transport of dangerous goods: Model regulations (Rev.17)
3 Terms and definitions
For the purposes of this document, the terms and definitions given in GB 13690 and the following apply.
3.1
germ cell mutagenicity
Chemicals cause mutations in human germ cells that may be passed on to future generations. When classifying substances and mixtures into this hazard category, pay attention to in vitro mutagenicity/genotoxicity test and in vivo mutagenicity and genotoxicity test of mammalian somatic cells. In this standard, terms mutagenicity, mutagen, mutation and genotoxicity will be mentioned many times. "Mutation" is defined as a permanent change in the quantity or structure of genetic material in cells.
The term "mutation" is applicable to dominant heritable genetic changes and potential DNA modifications (for example, known specific base-pairs transformation and chromosome translocation). The terms "mutagenicity" and "mutagen" apply to substances that cause an increase in the incidence of mutations in cells and/or organism communities.
Foreword i 1 Scope 2 Normative references 3 Terms and definitions 4 Classification standards 5 Judgment logic and guidance 6 Labelling Annex A (Informative) Judgment logic and guidance Annex B (Normative) Allocation of label elements Annex C (Normative) Classification standards and label elements of germ cell mutagenicity Annex D (Informative) Hazard statement and precautionary statement of germ cell mutagenicity Annex E (Informative) Label example of germ cell mutagenicity Annex F (Informative) Test items and standards related to germ cell mutagenicity
