Determination of dioxane residues in cosmetics for import and export - Gas chromatography-mass spectrometry method
1 Scope
This standard specifies the determination of dioxane residues in cosmetics by gas chromatography-mass spectrometry method.
This standard is applicable to the determination of dioxane residues in cosmetics.
The lower determination limit of dioxane in this standard is 2.5mg/kg.
2 Normative references
The following normative documents contain provisions which, through reference in this text, constitute provisions of this standard. For dated references, subsequent amendments (excluding corrections) to, or revisions of, any of these publications do not apply to this standard. However parties to agreements based on this standard are encouraged to investigate the possibility of applying the most recent editions of the normative documents indicated below. For undated references, the latest edition applies.
GB/T 6379 (All parts) Accuracy (trueness and precision) of measurement methods and results
3 Principle
Extract the sample in a headspace bottle after heating, then determine it by gas chromatography-mass spectrometry method (GC/MSD), quantify by external standard method and confirm by selected ion monitoring.
4 Reagents and materials
Unless otherwise specified, analytically pure reagents and Grade II water are adopted.
4.1 Dioxane: with a purity of 98%.
4.2 Dioxane standard stock solution: accurately weigh a proper amount of dioxane standard sample (accurate to 0.0001g), and prepare with water into standard stock solution with a concentration of 1,000μg/mL, then store the stock solution in a refrigerator at 4℃, valid for two months.
Foreword i
1 Scope
2 Normative references
3 Principle
4 Reagents and materials
5 Apparatus
6 Determination procedures
7 Calculation results
8 Precision
Annex A (Informative) GC/MS total ion chromatogram of dioxane reference material
Annex B (Informative) Recovery rate
