1 Scope
This standard specifies liquid chromatography tandem mass spectrometry of nonylphenol in cosmetics.
This standard applies to the determination of nonylphenol in such cosmetics as cream, loose powder, waters and lipstick.
For the purpose of this standard, the detection limit and quantitation limit of nonylphenol are 0.1 mg/kg and 0.2 mg/kg respectively.
2 Normative References
The following documents are indispensable for application of this standard. Any dated reference, only dated edition applies. For the undated reference, the latest edition (including any amendments) applies.
GB/T 6682 Water for Analytical Laboratory Use - Specification and Test Methods
3 Principle
Extract nonylphenol in cosmetics with methyl alcohol - methylene chloride mixed solution, purify the extracting solution by centrifugation and solid-phase extraction column, determine by liquid chromatography tandem mass spectrometry and quantify by internal standard method.
4 Reagents and Materials
Foreword i
Introduction ii
1 Scope
2 Normative References
3 Principle
4 Reagents and Materials
5 Apparatus
6 Determination Procedure
7 Result Calculation
8 Detection Limit and Quantitation Limit
9 Recovery Rate and Precision
10 Permissible Deviation
Annex A (Informative) Structural Formula of Nonylphenol Standard
Annex B (Informative) Selected Iron Mass Chromatogram of Nonylphenol Standard and Internal Standard Substance