1 Scope
This standard specifies the liquid chromatography - tandem mass spectrometry of melengestrol acetate, chlormadinone acetate and megestrol acetate residues in milk and milk powder.
This standard is applicable to the determination of melengestrol acetate, chlormadinone acetate and megestrol acetate residues in milk and milk powder.
The detection limits of the method in this standard: the detection limits of melengestrol acetate, megestrol acetate and chlormadinone acetate in milk and in milk powder are 2μg/kg and 20μg/kg respectively.
2 Normative References
The following documents contain provisions which, through reference in this text, constitute provisions of this standard. For dated reference, subsequent amendments to (excluding any corrigendum), or revisions of, any of these publications do not apply. However, parties to agreements based on this standard are encouraged to investigate the possibility of applying the most recent editions of the standards indicated below. For any undated references, the latest edition of the document referred to applies.
GB/T 6379.1 Accuracy (Trueness and Precision) of Measurement Methods and Results – Part 1: General Principles and Definitions (GB/T 6379.1-2004, ISO 5725-1:1994, IDT)
GB/T 6379.2 Accuracy (Trueness and Precision) of Measurement Methods and Results – Part 2: Basic Method for the Determination of Repeatability and Reproducibility of a Standard Measurement Method (GB/T 6379.2-2004, ISO 5725-2:1994, IDT)
GB/T 6682 Water for Analytical Laboratory Use – Specification and Test Methods (GB/T 6682-2008, ISO 3696:1987, MOD)
3 Principle
Foreword i
1 Scope
2 Normative References
3 Principle
4 Reagents and Materials
5 Apparatus
6 Preparation and Preservation of Specimen
7 Determination Procedures
8 Calculation of Result
9 Precision
Appendix A (Informative) Multi-response Monitoring (MRM) Chromatogram of Standards
Appendix B (Informative) Recovery
